Fluoride in drinking water and osteosarcoma incidence rates in the continental United States among children and adolescents


We found no sex-specific statistical differences in the national incidence rates in the younger groups (5–9, 10–14), although 15–19 males were at higher risk to osteosarcoma than females in the same age group (p < 0.001). Sex and age group specific incidence rates were similar in both CWF state categories. The higher incidence rates among 15–19 year old males vs females was not associated with the state fluoridation status. We also compared sex and age specific osteosarcoma incidence rates cumulated from 1973 to 2007 from the SEER 9 Cancer Registries for single age groups from 5 to 19. There were no statistical differences between sexes for 5–14 year old children although incidence rates for single age groups for 15–19 year old males were significantly higher than for females.


Our ecological analysis suggests that the water fluoridation status in the continental U.S. has no influence on osteosarcoma incidence rates during childhood and adolescence.

Cancer Epidemiology

April 2012, Vol.36(2):e83–e88, doi:10.1016/j.canep.2011.11.008
Michael Levy, Bernard-Simon Leclerc

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