Three hundred and eight osteosarcoma cases, 598 leukemia controls, and 604 CNS tumor controls met selection criteria and were assigned a corresponding PWS fluoride level. PWS fluoride level was not associated with osteosarcoma, either in a univariable analysis or after adjusting for age, sex, race, and poverty index. Stratified analyses by sex were conducted; no association between PWS fluoride level and osteosarcoma was observed among either males or females.


No relationship was found between fluoride levels in public drinking water and childhood/adolescent osteosarcoma in Texas.

Fluoride exposure in public drinking water and childhood and adolescent osteosarcoma in Texas
Natalie P. Archer , Thomas S. Napier, John F. Villanacci
Cancer Causes & Control. pp 1-6
DOI: 10.1007%2Fs10552-016-0759-9
First online: 17 May 2016

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