Many decades of epidemiological studies have shown minimal evidence of any effects of fluoride administration on bone, and it is therefore very unlikely that municipally fluoridated water affects adults with healthy bone. In this study, no effects of fluoride on mineralization (by BSE) and no substantive negative effects of fluoride administration on bone mechanical properties were observed. Our analysis of samples at the tissue level, rather than the population level, reveals high levels of variability in response to water fluoridation, which may account for the lack of differences observed in epidemiological studies (McDonagh et al., 2000). While we cannot definitively rule out an effect of low-level fluoride accumulation over long periods of time, especially if specific individuals have a genetic or disease background that renders them unusually susceptible to fluoride, it nevertheless appears that the contributors to bone health are too many and varied, and any possible effect of municipal fluoride ingestion is too small, for municipal water fluoridation to be a significant determinant of bone health within the general public.
Effects of Water Fluoridation on the Human Skeleton
D. Chachra, H. Limeback, T.L. Willett, and M.D. Grynpas
Journal of dental research 89(11):1219-23 · October 2010