Effect of Reduced Fluoride Intake By Mice on Haemocrit Values
Many attempts to demonstrate the dietary essentiality of fluoride have yielded equivocal results and none of the studies have connected fluoride to a specific metabolic deficiency (refs. 1-5 and personal communication from K. Schwartz). Undoubtedly, these studies have been hampered by the ubiquitous occurrence of fluoride in nature foods and water with the result that it has been very difficult to prepare a diet devoid of fluoride but nutritionally adequate in all other respects. In the work now reported, we took advantage of the low fluoride contents of milk and cereals to prepare a diet of very low fluoride content compared with that of commonly used rodent foods. Through use we found that haemopoiesis is markedly disturbed and the addition of fluoride to the intakes of the animals prevented this abnormality.
H.H. Messner, Kam Wong, Mary Wegner, L. Singer, & W.D. Armstrong
nature new biology 240, 218-219 (13 December, 1972)/ doi:10.1038/newbio240218a0
Fertility Impairment in Mice on a Low Fluoride Intake
Female mice maintained on a low fluoride diet over two generations showed a progressive decline in litter production. Mice receiving the same diet supplemented with fluoride reproduced normally and at consistent intervals. Addition of fluoride to the intake of females with demonstrated impaired fertility restored their reproductive capacity.
H.H. Messner, W.D. Armstrong, L. Singer
Science Vol 177, Issue 4052
08 September 1972